Genome engineering technologies, such as Zinc finger nucleases (ZFNs), TAL effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas) nucleases (CRISPR/Cas), achieve a "revolution" in life science and medical science.
These techniques allow us to manipulate genes of interest for several purposes,
1) functional gene annotation in vitro and in vivo.
2) production of animal models of human diseases.
3) establishment of a gene therapy platform.
We are therefore interesting in such new technologies, especially focusing on generating "humanized animals" or "immunodeficient animals". These valuable animals can engraft with human cells/tissues including human iPS-derived cells.
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